3/31/2024 0 Comments Mean intercept analysis stereology![]() The application of stereology to volumetric CT imaging enabled comprehensive quantification of total lung volume, volume fractions of alveolar, alveolar duct, and tissue, mean linear intercept, alveolar surface area, alveolar surface area density, septal wall thickness, alveolar number, number-weighted mean alveolar volume, and the number and morphometry of terminal and transitional bronchioles. Systematic uniform random samples were taken, scanned using micro-CT, and assessed using stereology. Nontransplantable donor lungs from individuals with no evidence of respiratory disease ( n = 13) were air inflated, frozen at 10 cmH 2O, and scanned using CT. ![]() Our objective was to demonstrate the application of stereology to volumetric multiresolution computed tomography (CT) to efficiently and extensively quantify the human lung anatomy. However, these techniques are labor intensive, involving fixation, embedding, and histological sectioning of samples and thus have prevented comprehensive studies. The application of stereology to lung casts and two-dimensional microscopy images is the gold standard for quantification of the human lung anatomy.
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